Sorry if I'm raising a suggestion that has already be discussed. I've just tried out the calligraphic preset option in the May 22 Win32 snapshot.
When you select a preset and make a change, instead of the preset selection jumping to "No preset" can the preset selection remain except with a "*" beside the name (i.e. Marker*)? This will make it easier to identify which preset you had been using before making a change.
When you choose to save the changes, populate the "Profile name" (should that be changed to "preset name"?) with the select preset name so you can easily save over it.
With these changes you could change "No preset" to "Default" and allow users to easily define their own default.
In my work I'll probably create a few presets combinations such as "Slow thin" and "Fast fat" etc. But every drawing will be slightly different, and in some cases the same part of the same drawing might require tweaking of the settings. So being able to quickly tweak and save my presets would be an useful feature.